Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

摘要: To examine signal transduction events activated by oncogenic p21ras, we have studied kinases that are following the scrape loading of p21ras into quiescent cells. We observe rapid activation 42 kDa and 46 protein kinases. The kinase is mitogen extracellular-signal regulated ERK2, (MAP2 kinase), which phosphorylation on tyrosine threonine in response to while likely be another member ERK family. Stimulation these does not require presence growth factors, showing uncouples from external signals. In ras transformed cell lines, constitutively activated. propose important components pathway oncoprotein.