Hypocholesterolemic and Antiatherosclerotic Potential of Basella alba Leaf Extract in Hypercholesterolemia-Induced Rabbits.

摘要: Hypercholesterolemia is the major risk factor that leads to atherosclerosis. Nowadays, alternative treatment using medicinal plants gained much attention since usage of statins adverse health effects, especially liver and muscle toxicity. This study was designed investigate hypocholesterolemic antiatherosclerotic effects Basella alba (B. alba) hypercholesterolemia-induced rabbits. Twenty New Zealand white rabbits were divided into 5 groups fed with varying diets: normal diet, 2% high cholesterol diet (HCD), HCD + 10 mg/kg simvastatin, 100 mg/kg B. extract, 200 mg/kg respectively. The extract significantly lowered levels total cholesterol, LDL, triglycerides increased HDL antioxidant enzymes (SOD GPx) levels. elevated (AST ALT) creatine kinase noted in hypercholesterolemic statin treated indicating injuries. Treatment also suppressed aortic plaque formation reduced intima: media ratio as observed simvastatin-treated group. first vivo on suggests its potential an therapeutic agent for hypercholesterolemia