Intracellular IL-4, IL-5, and IFN-γ as the main characteristic of CD4+CD30+ T cells after allergen stimulation in patients with vernal keratoconjunctivitis

作者: Diana Magaña , Gustavo Aguilar , Marisela Linares , Julio Ayala-Balboa , Concepción Santacruz

DOI:

关键词: Interleukin 5Vernal keratoconjunctivitisAllergic conjunctivitisAllergenMedicineImmunologyInterleukin 4ConjunctivaPeripheral blood mononuclear cellCD3

摘要: Background Vernal keratoconjunctivitis (VKC) is a severe form of allergic conjunctivitis, in which inflammatory infiltrates the conjunctiva are characterized by CD3+ and CD30+ cells. Until today, functional involvement T cells VKC was unclear. Our aim to evaluate characteristics after allergen stimulation peripheral blood mononuclear obtained from patients with VKC.

参考文章(16)
A. Leonardi, A. Di Stefano, L. Motterle, B. Zavan, G. Abatangelo, P. Brun, Transforming growth factor-β/Smad - signalling pathway and conjunctival remodelling in vernal keratoconjunctivitis. Clinical & Experimental Allergy. ,vol. 41, pp. 52- 60 ,(2011) , 10.1111/J.1365-2222.2010.03626.X
David R. Withers, Fabrina M. Gaspal, Vasileios Bekiaris, Fiona M. McConnell, MiYeon Kim, Graham Anderson, Peter J.L. Lane, OX40 and CD30 signals in CD4+ T-cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4+ T-cell memory but not effector function Immunological Reviews. ,vol. 244, pp. 134- 148 ,(2011) , 10.1111/J.1600-065X.2011.01057.X
Hinrich P. Hansen, Sebastian Dietrich, Tatiana Kisseleva, Thilo Mokros, Rolf Mentlein, Hans H. Lange, Gillian Murphy, Hilmar Lemke, CD30 Shedding from Karpas 299 Lymphoma Cells Is Mediated by TNF-α-Converting Enzyme Journal of Immunology. ,vol. 165, pp. 6703- 6709 ,(2000) , 10.4049/JIMMUNOL.165.12.6703
H M Jäck, T M Ellis, M Alzona, R I Fisher, CD30 defines a subset of activated human T cells that produce IFN-gamma and IL-5 and exhibit enhanced B cell helper activity. Journal of Immunology. ,vol. 153, pp. 2861- 2867 ,(1994)
Vincent Lombardi, Abinav K. Singh, Omid Akbari, The Role of Costimulatory Molecules in Allergic Disease and Asthma International Archives of Allergy and Immunology. ,vol. 151, pp. 179- 189 ,(2010) , 10.1159/000242355
Y. Garfias, B. Ortiz, J. Hernández, D. Magaña, M. Becerril-Angeles, E. Zenteno, R. Lascurain, CD4+ CD30+ T cells perpetuate IL-5 production in Dermatophagoides pteronyssinus allergic patients. Allergy. ,vol. 61, pp. 27- 34 ,(2006) , 10.1111/J.1398-9995.2005.00951.X
Andrea Leonardi, Iva A. Fregona, Mario Plebani, Antonio G. Secchi, Virginia L. Calder, Th1- and Th2-type cytokines in chronic ocular allergy Graefes Archive for Clinical and Experimental Ophthalmology. ,vol. 244, pp. 1240- 1245 ,(2006) , 10.1007/S00417-006-0285-7
Enrique Rojas-Ramos, Yonathan Garfias, María del Carmen Jiménez-Martínez, Norma Martínez-Jiménez, Edgar Zenteno, Patricia Gorocica, Ricardo Lascurain, None, Increased expression of CD30 and CD57 molecules on CD4 T cells from children with atopic asthma: A preliminary report Allergy and Asthma Proceedings. ,vol. 28, pp. 659- 666 ,(2007) , 10.2500/AAP.2007.28.3057
Atsuki Fukushima, Tomoko Yamaguchi, Ken Fukuda, Tamaki Sumi, Naoki Kumagai, Teruo Nishida, Shosuke Imai, Hisayuki Ueno, CD8+ T cells play disparate roles in the induction and the effector phases of murine experimental allergic conjunctivitis. Microbiology and Immunology. ,vol. 50, pp. 719- 728 ,(2006) , 10.1111/J.1348-0421.2006.TB03845.X
Anne Kotaniemi-Syrjänen, Weronika Delezuch, Anna S. Pelkonen, Kristiina Malmström, L. Pekka Malmberg, Kari Punnonen, Irma H. Matinlauri, Mika J. Mäkelä, Improvement in lung function is associated with a decrease in serum soluble CD30 in atopic infants Annals of Allergy Asthma & Immunology. ,vol. 114, pp. 156- 157 ,(2015) , 10.1016/J.ANAI.2014.11.011