Increased expression of putative cancer stem cell markers in the bone marrow of prostate cancer patients is associated with bone metastasis progression.
作者： Estelle Ricci , Eve Mattei , Charles Dumontet , Colby L. Eaton , Freddy Hamdy
DOI: 10.1002/PROS.22689
关键词: Pathology 、 Prostate cancer 、 Bone metastasis 、 Stem cell marker 、 Cancer stem cell 、 Metastasis 、 PCA3 、 Bone Marrow Flow Cytometry 、 Medicine 、 Bone marrow
摘要: BACKGROUND The number of cells positive for the α-6 and α-2 integrin subunits c-Met receptor in primary tumors bone biopsies from prostate cancer patients has been correlated with metastasis disease progression. The objective this study was to quantify disseminated tumour present marrow using specific markers determine their correlation survival. METHODS Patients were included at different stage disease, localised metastatic castration-resistant cancer. Healthy men used as a control group. Bone samples collected nucleated separated. These stained CD45, α-2, processed analysis quantification CD45-/α2+/α6+/c-met + flow cytometry. Clinical pathological parameters assessed survival measured. Statistical analyses made associations between parameters, cytometry data, prostate-specific antigen (PSA) progression free metastases survival. RESULTS For all markers, presence more than 0.1% aspirates significantly associated risk biochemical progression, developing death cancer. CONCLUSIONS Quantification carrying putative stem cell is potential indicator Functional studies on isolated are needed show specifically property spread
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