Effect of neural transplantation on depressive behavior in rats with lesioned nucleus basalis magnocellularis.
作者： NATALIJA POPOVIC , MIROLJUB POPOVIC , KATICA JOVANOVA-NESIC , DUBRAVKO BOKONJIC , VLADIMIR S. KOSTIC
关键词: Nucleus basalis 、 Transplantation 、 Learned helplessness 、 Brain Tissue Transplantation 、 Escape response 、 Central nervous system 、 Lesion 、 Internal medicine 、 Endocrinology 、 Psychology 、 Frontal lobe 、 Neuroscience
摘要: Recent data of our group have shown that bilateral electrolytic lesions the nucleus basalis magnocellularis (NBM) in rats reduced escape behavior deficit occurs learned helplessness test. The present study was done to establish effect intracerebral neural transplantation on change NBM-lesioned adult male Wistar At 2 days (NBM-ET) or 10 (NBM-DT) after NBM-lesions, small fragments fetal frontal cortex (18th day gestation) were allotransplanted into lesioned NBM. Ten transplantation, test performed. number shocks animals received before making an response significantly (p < .001, compared intact control and sham-operated rats). In comparison sham-ET rats, NBM-ET showed a marked .001) increase delivered animal made such response. On other hand, NBM-DT did not show this increase. These results indicate performed at early time lesioning NBM reversed lesion exposed
sci-hub.se 参考文章(37)
Michel Roger, Frédéric Gaillard, Afsaneh Gaillard, Neocortical Grafting to Newborn and Adult Rats: Developmental, Anatomical and Functional Aspects ,(1998)
L Teri, Behavior and caregiver burden: behavioral problems in patients with Alzheimer disease and its association with caregiver distress. Alzheimer Disease & Associated Disorders. ,vol. 11, ,(1997)
Miroljub Popovi?, Natalija Popovi?, Dubravko Bokonji?, Silva Dobri?, Nenad Ugre?i?, Vladimir S. Kosti?, Effect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularis Neuroscience Research Communications. ,vol. 23, pp. 13- 22 ,(1998) , 10.1002/(SICI)1520-6769(199807/08)23:1<13::AID-NRC2>3.0.CO;2-O
S. B. Dunnett, S.-J. Richards, Neural transplantation : from molecular basis to clinical applications Elsevier , Sole distributors for the USA and Canada, Elsevier Science Pub. Co.. ,(1990)
G. Lo Conte, L. Bartolini, F. Casamenti, I. Marconcini-Pepeu, G. Pepeu, Lesions of cholinergic forebrain nuclei: Changes in avoidance behavior and scopolamine actions Pharmacology Biochemistry and Behavior. ,vol. 17, pp. 933- 937 ,(1982) , 10.1016/0091-3057(82)90475-0
Cyril Garnier, Patricia Arnault, Michel Roger, Development of the striatal projection from embryonic neurons from the lateral or medial frontal cortex grafted homo- or heterotopically into the medial frontal cortex of newborn rats Neuroscience Letters. ,vol. 235, pp. 41- 44 ,(1997) , 10.1016/S0304-3940(97)00691-5
Gwenn Smith, Animal models of Alzheimer's disease: experimental cholinergic denervation. Brain Research Reviews. ,vol. 13, pp. 103- 118 ,(1988) , 10.1016/0165-0173(88)90016-1
D. D. Dougherty, C. E. Sortwell, J. Sagen, Pharmacologic specificity of antidepressive activity by monoaminergic neural transplants Psychopharmacology. ,vol. 118, pp. 10- 18 ,(1995) , 10.1007/BF02245244
Steven C. Dilsaver, Cholinergic mechanisms in depression Brain Research. ,vol. 11, pp. 285- 316 ,(1986) , 10.1016/0165-0173(86)90016-0
Peter J Whitehouse, Donald L Price, Arthur W Clark, Joseph T Coyle, Mahlon R DeLong, None, Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis Annals of Neurology. ,vol. 10, pp. 122- 126 ,(1981) , 10.1002/ANA.410100203