Pharmacologic specificity of antidepressive activity by monoaminergic neural transplants

摘要: Previous studies in our laboratory have demonstrated the ability of monoaminergic transplants rat frontal cortex to produce antidepressive activity both learned helplessness model and forced swimming test, as well increase monoamine levels implanted cortex. These findings implicate increased cortical norepinephrine (NE) serotonin (5-HT) transplants. The goal present study was characterize pharmacologic mechanisms involved graft-induced activity. Immobility scores test (FST) were assessed after transplantation 5-HT-containing pineal gland tissue, NE-containing adrenal medullary a combination tissues, or sciatic nerve (control) into compared non-transplanted chronic imipramine-treated rats. Monoaminergic imipramine treatment significantly reduced immobility FST contrast control transplanted untreated animals. All groups pharmacologically with adrenergic antagonists phentolamine (α) propranolol (β), serotonergic metergoline (5-HT1/5-HT2) pirenperone (5-HT2). Serotonergic antagonists, particularly 5HT2 antagonist, blocked reduction induced by implants. Adrenergic not only reductions grafted animals, but overcompensated for transplants, producing large immobility. cografts all four antagonists. animals altered any produced propranolol. results indicate that sustained via local interaction withα-andβ-adrenergic receptors receptors, respectively, may be mediated distinct from antidepressant drugs.