Indoleamine 2,3-dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment

作者: Yuko Tanizaki , Aya Kobayashi , Saori Toujima , Michihisa Shiro , Mika Mizoguchi

DOI: 10.1111/CAS.12445

关键词: Natural killer cellOvarian cancerOvarian carcinomaT cellCD8ImmunologyTumor microenvironmentIndoleamine 2,3-dioxygenasePeritoneal cavityBiology

摘要: … of CD8 + T cells and natural killer cells within tumors as well as … cancer,6-8 although detailed mechanisms are still unclear. … Although single use of the IDO inhibitor 1-MT is currently …

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