Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impairment of spatial memory

摘要: The purpose of this study was to investigate the effect antioxidant ingestion on stress-induced impairment cognitive memory. Male C57BL/6 mice were divided into four groups as follows: (1) control (C mice) fed in a normal cage without immobilization; (2) restraint-stressed (RS small cage; (3) vitamin E (VE mice), with diet supplemented E; (4) GliSODin (GS GliSODin. RS, VE and GS exposed 12 h immobilization daily. Five weeks later, spatial learning measured using Morris Water Maze (MWM) test. After water maze testing, we performed immunohistochemical analysis 4-hydroxy-2-noneral (4-HNE) an anti-Ki67 antibody. 4-HNE is marker lipid peroxidation. RS showed impaired performance increased number 4-HNE-positive cells granule cell layer (GCL) hippocampal dentate gyrus when compared C mice. Moreover, decreased Ki67-positive subgranular zone (SGZ). better memory than GCL significantly less that SGZ greater These finding suggests prevents function maintains neurogenesis hippocampus through activity.