Drosophila as a Model for Human Diseases-Focus on Innate Immunity in Barrier Epithelia.

摘要: Epithelial immunity protects the host from harmful microbial invaders but also controls beneficial microbiota on epithelial surfaces. When this delicate balance between pathogen and symbiont is disturbed, clinical disease often occurs, such as in inflammatory bowel disease, cystic fibrosis, or atopic dermatitis, which all can be part linked to impairment of barrier epithelia. Many innate immune receptors, signaling pathways, effector molecules are evolutionarily conserved human Drosophila. This review describes current knowledge Drosophila a model for diseases, with special focus immune-related disorders gut, lung, skin. The discovery antimicrobial peptides, crucial role Toll Toll-like evolutionary conservation systems both described historical perspective. Similarities differences discussed; effectors reviewed, including reactive oxygen species, well autophagy. We give examples diseases appears useful model. In addition, limitations mentioned. Finally, we propose areas future research, include using drug screening, validation tool novel genetic mutations humans exploratory research microbiota-host interactions, relevance infection, wound healing, cancer.