Pilot Study: Alteration of Deleted in Liver Cancer1 and Phosphorylated Focal Adhesion Kinase Y397 Cytoplasmic Expression and the Prognostic Value in Advanced Epithelial Ovarian Carcinoma
作者： Dong-Mei Fan , Hui-Rong Shi
DOI: 10.3390/IJMS12128489
关键词: Case-control study 、 Ovarian carcinoma 、 Pathology 、 DLC1 、 Carcinoma 、 Focal adhesion 、 Cancer research 、 Liver cancer 、 Immunohistochemistry 、 Biology 、 Gene
摘要: Background: Deletion in liver cancer gene (DLC1) and phosphorylated focal adhesion kinase (p-FAK) have recently been reported as metastasis-related genes. However, the roles prognostic values of their expression epithelial ovarian carcinomas (EOCs) remain unclear. Methods: The value DLC1 p-FAK Y397 EOC were evaluated by immunohistochemistry multivariate analysis. Results: Low high found 76 cases EOC. negatively correlated. Multivariate analysis showed that combination them was an independent marker (P = 0.0319). Conclusions: pFAK had association with clinicopathologic characteristics Expression neither these genes a factor alone, but revealed significant 60 advanced stage
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