Endothelin-1 receptor density, distribution, and function in human isolated asthmatic airways.
作者： R G Goldie , P J Henry , P G Knott , G J Self , M A Luttmann
DOI: 10.1164/AJRCCM.152.5.7582310
关键词: Contraction (grammar) 、 Endocrinology 、 Bronchial obstruction 、 Smooth muscle 、 Asthma 、 Airway smooth muscle 、 Internal medicine 、 Density distribution 、 Endothelin-1 Receptor 、 Medicine 、 Immunology 、 Receptor
摘要: The potent bronchoconstrictor and mitogenic actions of the peptide endothelin-1 (ET-1) on airway smooth muscle may contribute significantly to bronchial obstruction observed in asthma. However, status receptor-effector systems that mediate these ET-1 asthmatic airways is currently unknown. Thus, we have used quantitative autoradiographic isometric-tension recording techniques evaluate density, distribution, function specific receptors both nonasthmatic airways. Here, report similar numbers binding sites for [125I]-ET-1 exist airways, with greatest densities located tissue types. ETB-receptor subtype constituted approximately 82% 88% human muscle, respectively, mediated contraction response this peptide. In addition, a component of...
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