Tuberculin Skin Tests versus Interferon-Gamma Release Assays in Tuberculosis Screening among Immigrant Visa Applicants
作者： Stella O. Chuke , Nguyen Thi Ngoc Yen , Kayla F. Laserson , Nguyen Huu Phuoc , Nguyen An Trinh
DOI: 10.1155/2014/217969
关键词: Mycobacterium tuberculosis 、 Interferon gamma 、 Medicine 、 Tuberculin 、 Pediatrics 、 Population 、 Tuberculosis 、 Research article 、 Tuberculosis screening 、 Predictive value
摘要: Objective. Use of tuberculin skin tests (TSTs) and interferon gamma release assays (IGRAs) as part tuberculosis (TB) screening among immigrants from high TB-burden countries has not been fully evaluated. Methods. Prevalence Mycobacterium infection (MTBI) based on TST, or the QuantiFERON-TB Gold test (QFT-G), was determined immigrant applicants in Vietnam bound for United States (US); factors associated with results discordance were assessed; predictive values TST QFT-G identifying chest radiographs (CXRs) consistent TB calculated. Results. Of 1,246 visa studied, 57.9% positive, 28.3% agreement 59.4%. Increasing age positive results, TST-positive but QFT-G-negative discordance, abnormal CXRs TB. Positive an CXR 25.9% 25.6%, respectively. Conclusion. The estimated prevalence MTBI US-bound twice that QFT-G, 14 times higher than a TST-based estimate reported general US population 2000. better at predicting
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