Selective trace enrichment of acidic pharmaceuticals in real water and sediment samples based on solid-phase extraction using multi-templates molecularly imprinted polymers
作者： Yan-Ping Duan , Chao-Meng Dai , Ya-Lei Zhang , Ling-Chen
DOI: 10.1016/J.ACA.2012.11.010
关键词: Molecular imprinting 、 Adsorption 、 Molecularly imprinted polymer 、 Solid phase extraction 、 Chemistry 、 Extraction (chemistry) 、 Toluene 、 Matrix (chemical analysis) 、 Solvent 、 Chromatography
摘要: A novel multi-templates molecularly imprinted polymer (MIP), using acidic pharmaceuticals mixture (ibuprofen (IBP), naproxen (NPX), ketoprofen (KEP), diclofenac (DFC), and clofibric acid (CA)) as the template, was prepared solid-phase extraction (SPE) material for quantitative enrichment of in environmental samples off-line coupled with liquid chromatography-mass spectrometry (LC/MS/MS). Washing solvent optimized terms kind volume removing matrix constituents nonspecifically adsorbed on MIP. When 1L water sample spiked at 1μg/L loaded onto cartridge, binding capacity MIP cartridge were 48.7μg/g KEP, 60.7μg/g NPX, 52μg/g CA, 61.3μg/g DFC IBP, respectively, which are higher than those commercial single template organic medium (e.g. toluene) reported literature. Recoveries five extracted from real such lake wastewater more 95%. The recoveries 10-g sediment 10ng/g level range 77.4-90.6%. To demonstrate potential obtained, a comparison C18 SPE performed. Molecularly (MISPE) showed pharmaceuticals. These results suitability MISPE method selective group structurally related compounds
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