Differential cytokine expression in myocytes and non-myocytes after myocardial infarction in rats.
作者： Alexander Deten , Hans Christian Volz , Wilfried Briest , Heinz-Gerd Zimmer
DOI: 10.1007/978-1-4757-4712-6_7
关键词: Endocrinology 、 Medicine 、 Myocyte 、 Proinflammatory cytokine 、 Interleukin 、 Heart failure 、 Internal medicine 、 Cardiology 、 Wound healing 、 Myocardial infarction 、 Hemodynamics 、 Clinical chemistry
摘要: The proinflammatory cytokines interleukin (IL)-1β and IL-6 are increased after acute myocardial infarction (MI). Moreover, serum level is elevated MI, but has also been associated with heart failure. In the present study, function was monitored in a rat model of chronic MI. Cytokine expression infarcted non-infarcted myocardium as well hearts sham-operated controls measured by ribonuclease-protection assay. To identify cells contributing to cytokine expression, we further analyzed myocytes non-myocytes isolated phase during congestive failure (CHF) There strong induction infarct area 6 h myocardium, only slightly h. This not different from may, therefore, be induced stress catecholamines. CHF, however, normal. It significantly 4 8 weeks conclusion, suggest that pro-inflammatory cytokines, produced ischemic may involved initiation wound healing necrotic area, whereas effect if any, seems crucial.
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