Glutamine-enriched intravenous feedings attenuate extracellular fluid expansion after a standard stress.

摘要: A double-blind, randomized controlled trial was performed to determine the effect of glutamine (GLN)-enriched intravenous feedings on volume and distribution body fluids in catabolic patients. Subjects with hematologic malignancies remission underwent a standard treatment high-dose chemotherapy total irradiation before bone marrow transplantation. After completion this regimen, they were receive either parenteral nutrition (STD, n = 10) or an isocaloric, isonitrogenous nutrient solution enriched crystalline L-glutamine (0.57 g/kg/day, GLN, 10). Extracellular water (ECW) (TBW), determined by bromide heavy dilution techniques, measured conditioning after termination that administered for 27 +/- 1 days. In addition electrical resistance (R, ohms, omega) reactance (Xc, weak alternating current at these time points. Both study groups comparable age, weight, height, sex, diagnosis. Initial TBW highly related (r -0.93, p less than 0.001). therapy, infusion, feedings, 20% expansion ECW observed STD group (ECW: 18.0 1.1 L vs. 14.9 1.0, 0.012), fluid retention associated marked decrease (R: 514 28 omega 558 26, 0.05). contrast extracellular compartment patients receiving GLN-supplementation did not change 15.8 0.9 15.4 0.8, 0.49), body's maintained 552 565 23, 0.42). Expansion could be differences sodium intake, use diuretics steroids. Patients solution, however, exhibited greater number positive microbial cultures (p 0.01) higher rate clinical infection compared GLN (5/10 0/10, 0.05); infected uninfected individuals (delta ECW: + 5.0 1.4 0.7 0.5, 0.007). model stress, commonly can attenuated administering glutamine-supplemented possibly protecting host from invasion infection.