Francisella tularensis in muscle from diseased hares - a risk factor for humans?

摘要: Tularemia caused by the bacterium Francisella tularensis is a zoonotic disease. common disease in hare, and as game species can be an important source of infection for humans. In this study, hares diagnosed with tularemia were examined aim to investigate whether muscle (meat) had any pathological changes and/or contained F. tularensis. Real-time PCR immunohistochemistry (IHC) detected bacteria samples from 40 out 43 investigated hares. IHC showed that few most commonly located peri- endomysium. Histopathology occasional perimysial necroses mild inflammation association bacteria. Attempts culture 14 successful two cases, both stored freezer <1 year. The result study shows since present infected hares, there risk human when consuming undercooked hare meat. enhanced fact some do not have easily gross lesions. contributes better understanding sources factors humans contract tularemia.