A Retrospective Assessment of the Use of Naltrexone Implants for the Treatment of Problematic Amphetamine Use

摘要: Background At present there is no registered effective pharmacotherapy for the treatment of problematic amphetamine use. Objectives This study aims to examine self-reported abstinence from amphetamines following with a sustained release naltrexone preparation in patients self and clinically identified problems use relationship between blood levels amphetamines. Methods Forty-four use, who were treated implant, completed an interview evaluating reduction treatment. Additional data collected patients' clinical files. Results Of 44 subjects, 29 (65.9%) interviewed reported that they ceased using maintained at least 1 month. Of these patients, 14 (48.3%) reportedly still abstinent 6 months. Rates found be 2.27 times higher (95% CI 1.38–3.74) when above 2 ng/ml, rates as high 100% 90.9% ≥5 ≥2 ng/ml, respectively, compared 42.9% 1–2 ng/ml 38.9% low less than 1 ng/ml. Conclusions Although this has several limitations, findings provide preliminary support implant suggest 2 ng/ml should targeted patients. Scientific Significance Data supports naltrexone, which currently pharmacotherapy. However, further research required. (Am J Addict 2013;22:1-6)