Naltrexone attenuates acute cigarette smoking behavior

摘要: This within-subjects, placebo-controlled laboratory study was designed to examine the effects of naltrexone on cigarette response in 44 chronic smokers (23 male, 21 female). Each participant received either 50-mg oral or identical placebo during morning session after maintaining overnight abstinence. Subsequently, administered a smoking cue (holding lit cigarette) craving and associated features smoking, instructed smoke 1 h later. followed by interval which participants could choose up four more cigarettes over 2-h period. Subjective measures (withdrawal, craving, affect, side effects) behavior were assessed throughout session. Naltrexone significantly reduced total number choice smoked expired carbon monoxide levels (Ps<.05). increased effects, especially for sedation (P<.01). Further, overall negative decreased positive affect first However, did not acute withdrawal urges. Despite mixed findings, women reported naltrexone-induced (P<.05) (P<.08) compared men. Although exact mechanism is unknown, findings support an opioid antagonist attenuation behavior.