Design of a Highly Sensitive and Specific Nucleotide Sensor Based on Photon Upconverting Particles

摘要: We have designed and developed a novel sensor that reports the presence of specific nucleic acids in solutions, based on photon upconverting particles. The significantly high signal-to-noise ratio particles leads to sensitivity sensor. does not suffer from photobleaching. It also displays specificity self-calibrating capability. expect nucleotide sensors this type be effective for applications both DNA/RNA detection protein-DNA/RNA interaction studies.