Antiproliferative evaluation of tall-oil docosanol and tetracosanol over CHO-K1 and human melanoma cells
作者： Mauricio Vergara , Araceli Olivares , Claudia Altamirano
DOI: 10.1016/J.EJBT.2015.05.004
关键词: Docosanol 、 Human melanoma 、 Future studies 、 Cancer research 、 Pinus <genus> 、 Cell 、 Immunology 、 Biology 、 Tall oil 、 Cell culture 、 Melanoma
摘要: abstract Article history:Received 21 January 2015Accepted 2 May 2015Available online 28 2015Keywords:CHO-K1 cellsGrowth-arrestedHuman melanoma cellsPolycosanols Background:Polycosanolsderivedfromplantspecieshavetraditionallybeenusedinmedicineasantiproliferativeagentsfortreatingvariousviruses(primarilytheherpessimplexvirus).However,fewstudieshavestudiedtheireffects on hyperproliferative cell lines. In this work, the antiproliferative capacity of polycosanols from tall-oilpitch, obtained black liquor soaps in kraft pulping process cellulose (specifically Pinus radiata,Pinus taede,andEucalyptus globulus), was evaluated CHO-K1 and CRL-1974 human lines.Results: The proliferative capacities viabilities were measured for 72 140 h, respectively. TreatmentwithdocosanolproduceddifferentialeffectsontheCHO-K1andhumanmelanomacellsandsignificantlyaffectedtheir proliferation rates, but not their viabilities. Tetracosanol produced a significant negative effect theproliferation cells, less than that caused by docosanol. However, it hadno cells did induce any viability thestudied lines.Conclusion: Docosanol tetracosanol induced effects studied lines exhibitedsignificantly greater oncogenic Prior to study, these polycosanolshas never been investigated. Future studies will be necessary determine mechanisms action onthese systems.©2015Pontificia UniversidadCatolicadeValparaiso. Production hosting byElsevierB.V. Allrights reserved.
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