Geographical and temporal variations in clozapine prescription for schizophrenia

摘要: Despite its unsurpassed efficacy in treatment-resistant schizophrenia, clozapine remains underutilized. Trends the prescription of patients with ICD-10 F20.x schizophrenia were assessed using data from Danish national registers. Three substudies carried out: (i) an assessment differences patterns between 1996 and 2007 a cross-sectional design; (ii) comparison time first diagnosis to five-year cohort study, Cox regression model, two patient groups who diagnosed 2003; (iii) general psychiatric hospitals' use 2009. The results are as follows: percentage receiving rose 9.0% 10.1% (p<0.001). In same period, having treatment augmented another antipsychotic increased 43.1% 64.2%, p<0.001. Time until was longer for 2003 compared those (HR: 0.28 CI: 0.16-0.49). 2009 there significant variation administration one hospital other, percentages drug ranging 5.7% 16.8%, 10.2% mean. Although, 2007, increased.