FGF receptors: cancer biology and therapeutics.

作者: Masaru Katoh , Hitoshi Nakagama

DOI: 10.1002/MED.21288

关键词: Fibroblast growth factorCancer researchWnt signaling pathwayAlveolar rhabdomyosarcomaEstrogen receptorFibroblast growth factor receptor 1BiologyFibroblast growth factor receptorPonatinibUterine cancer

摘要: … Dovitinib, ponatinib, and AZD4547 are currently in clinical trial as anticancer drugs. … signaling cascade in a positive feedback regulation mechanism.61-63 FGF2 signaling to MAPK also …

参考文章(167)
Fanyin Meng, Shannon S. Glaser, Heather Francis, Sharon DeMorrow, Yuyan Han, Jenna D. Passarini, Allison Stokes, John P. Cleary, Xiuping Liu, Julie Venter, Preetham Kumar, Sally Priester, Levi Hubble, Dustin Staloch, Jay Sharma, Chang-Gong Liu, Gianfranco Alpini, Functional analysis of microRNAs in human hepatocellular cancer stem cells Journal of Cellular and Molecular Medicine. ,vol. 16, pp. 160- 173 ,(2012) , 10.1111/J.1582-4934.2011.01282.X
Debbie L. Cunningham, Steve M. M. Sweet, Helen J. Cooper, John K. Heath, Differential phosphoproteomics of fibroblast growth factor signaling: identification of Src family kinase-mediated phosphorylation events. Journal of Proteome Research. ,vol. 9, pp. 2317- 2328 ,(2010) , 10.1021/PR9010475
Rosa Serra, Stephanie L. Easter, Wen Jiang, Sarah E. Baxley, Wnt5a as an Effector of TGFβ in Mammary Development and Cancer Journal of Mammary Gland Biology and Neoplasia. ,vol. 16, pp. 157- 167 ,(2011) , 10.1007/S10911-011-9205-5
Jean Paul Thiery, Epithelial–mesenchymal transitions in tumour progression Nature Reviews Cancer. ,vol. 2, pp. 442- 454 ,(2002) , 10.1038/NRC822
William Reardon, Robin M. Winter, Paul Rutland, Louise J. Pulleyn, Barry M. Jones, Sue Malcolm, Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome. Nature Genetics. ,vol. 8, pp. 98- 103 ,(1994) , 10.1038/NG0994-98
Giampaolo Tortora, Fortunato Ciardiello, Giampietro Gasparini, Combined targeting of EGFR-dependent and VEGF-dependent pathways: rationale, preclinical studies and clinical applications Nature Reviews Clinical Oncology. ,vol. 5, pp. 521- 530 ,(2008) , 10.1038/NCPONC1161
Jianming Zhang, Priscilla L. Yang, Nathanael S. Gray, Targeting cancer with small molecule kinase inhibitors Nature Reviews Cancer. ,vol. 9, pp. 28- 39 ,(2009) , 10.1038/NRC2559
Richard Grose, Clive Dickson, Fibroblast growth factor signaling in tumorigenesis Cytokine & Growth Factor Reviews. ,vol. 16, pp. 179- 186 ,(2005) , 10.1016/J.CYTOGFR.2005.01.003
L. Mologni, Development of RET kinase inhibitors for targeted cancer therapy. Current Medicinal Chemistry. ,vol. 18, pp. 162- 175 ,(2011) , 10.2174/092986711794088308
Anna Vecchione, Helen J. Cooper, Kimberley J. Trim, Shiva Akbarzadeh, John K. Heath, Lee M. Wheldon, Protein partners in the life history of activated fibroblast growth factor receptors Proteomics. ,vol. 7, pp. 4565- 4578 ,(2007) , 10.1002/PMIC.200700615