Association of XRCC1 gene polymorphisms with susceptibility to gastric cancer in Chinese Han population

摘要: Objectives Gastric cancer is one of the most frequently causing cancer-related deaths worldwide. The X-ray repair complementing group 1 gene (XRCC1) an important candidate for influencing gastric risk. This study aimed to evaluate associations between XRCC1 genetic variants and susceptibility in Chinese Han population. Methods Four hundred twenty-four patients 430 cancer-free controls were enrolled. Two (c.1254C>T c.1779C>G) genotyped by created restriction site-polymerase chain reaction (PCR) PCR-restriction fragment length polymorphism methods, respectively. Key findings Results from this indicated that allele genotype frequencies these two statistically different controls. association analyses suggested associated with increased risk (for c.1254C>T, T versus C: odds ratio (OR) = 1.44, 95% confidence interval (CI) 1.17–1.77; c.1779C>G, G OR = 1.51, CI 1.22–1.86). allele-T c.1254C>T allele-G c.1779C>G may contribute population. Conclusion Our data suggest might be used as molecular markers evaluating cancer.