Characterization of the Large Picornaviral Polypeptides Produced in the Presence of Zinc Ion
作者： Byron E. Butterworth , Bruce D. Korant
DOI: 10.1128/JVI.14.2.282-291.1974
关键词: Zinc 、 Viral protein processing 、 Capsid 、 Polyacrylamide gel electrophoresis 、 Gene 、 Poliovirus 、 Virus 、 Biochemistry 、 Biology 、 Peptide Biosynthesis 、 Molecular biology 、 Immunology 、 Insect Science 、 Microbiology 、 Virology
摘要: Zinc ion inhibits the posttranslational cleavages of human rhinovirus-1A, encephalomyocarditis virus, and poliovirus polypeptides. Each virus displayed a different susceptibility to zinc. However, in each case capsid precursor analogous C --> D E conversion were most sensitive Higher concentrations zinc resulted buildup even larger polypeptides size between 106,000 214,000 daltons. The sizes these relative position their gene loci on viral RNA determined. These data used place over-all scheme protein processing.
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