Capping of lymphocytes in patients and carriers of duchenne muscular dystrophy

摘要: Recent results showed that Duchenne muscular dystrophy is probably associated with a generalized membrane defect. The capping phenomenon in lymphocytes indicates normal intramembrane protein mobility and disturbances of this are believed to reflect alterations. We have investigated from 19 patients dystrophy, 13 carriers, 8 patients' sisters, 14 aunts 52 controls. All reduction both fluorescein conjugated polyvalent goat antiserum (mean +/- SD = 18.5 5.1% labeled Concanavalin A 10.8 3.1%) as compared Normal persons (n 52) mean 50.2 9.9% (SD) anti-immunoglobulin (range: 32--72.5%) 25.6 3.6% F-Con 18.5--31.5%). 12 the mothers, well 5 also exhibited decreased lymphocyte same extent patients. Creatine kinase activity (CK) was elevated only 4 mothers 2 sisters. Our indicate method might be value detecting carriers can yield less false negative CK-activity test.