Evaluation of Omeprazole in the Treatment of Reflux Laryngitis: A Prospective, Placebo‐Controlled, Randomized, Double‐Blind Study

摘要: Objectives Proton-pump inhibitors are often recommended in the treatment of laryngitis secondary to gastric reflux. Despite prospective studies reporting high efficacy, only one previous report has been placebo-controlled and blinded. The objective this study was determine efficacy omeprazole treating proven reflux laryngitis. Study Design Prospective, placebo-controlled, randomized, double-blind clinical trial. Methods Fifty-three patients with or more symptoms were recruited undergo 24-hour dual-channel pH probe testing. Thirty than four episodes laryngopharyngeal enrolled. By random assignment, 15 received 40 mg twice a day other placebo for period 2 months. Symptoms (hoarseness, throat pain, lump sensation, clearing, cough, excessive phlegm, dysphagia, odynophagia, heartburn) endoscopic laryngeal signs (erythema, edema, mucus accumulation) recorded initially, at 1 month, months. Results In general, most symptom scores improved over time both groups. Hoarseness, when begin low hoarseness scores, clearing significantly on those during 2-month study. Throat difficulty swallowing, pain heartburn showed improvement arms, signifying possibility effect. Endoscopic did not change course either group. Conclusions A effect appears exist laryngitis. However, hoarseness, initially scored low, resulting from effectively treated by omeprazole.