The Effect of Consumption of Citrus Fruit and Olive Leaf Extract on Lipid Metabolism

摘要: Citrus fruit and olive leaves are a source of bioactive compounds such as biophenols which have been shown to ameliorate obesity-related conditions through their anti-hyperlipidemic anti-inflammatory effect, by regulating lipoproteins cholesterol body levels. Citrolive™ is commercial extract obtained from the combination both citrus leaf extracts; hence, it hypothesised that may moderate metabolic disorders related obesity complications. Initially, an in vitro study inhibition pancreatic lipase activity was made, however, no effect found. Both preliminary long-term evaluations on lipid metabolism were conducted animal model using Wistar rats. In vivo screening, tested postprandial plasma triglyceride level after administration oil emulsion, significant reduction triacylglycerol (TAG) levels observed. study, administered for 60 days rats fed high-fat diet. During several associated indicators analysed blood faeces. At end experiment, livers removed weighed group comparison. treatment significantly reduced liver-to-body-weight ratio, supported transaminases compared with control, but insignificantly low density lipoprotein (LDL) TAG addition, faecal analysis showed increased total excretion. On other hand, found vitro. conclusion, ameliorates liver inflammation symptoms worsened effects high fat