FOXO3 as a new IKK-ε-controlled check-point of regulation of IFN-β expression.
作者： Lionel Luron , David Saliba , Katrina Blazek , Alessandra Lanfrancotti , Irina A. Udalova
关键词: Cancer research 、 HEK 293 cells 、 IκB kinase 、 Cytokine 、 Transcription factor 、 Cell biology 、 FOXO3 、 TLR4 、 Biology 、 Interferon regulatory factors 、 Interferon
摘要: Cell survival transcription factor FOXO3 has been recently implicated in moderating pro-inflammatory cytokine production by dendritic cells (DCs), but the molecular mechanisms are unclear. It was suggested that could antagonize NF-κB activity, while IKK-β demonstrated to inactivate FOXO3, suggesting a cross-talk between two pathways. Therefore, activity must be tightly regulated allow for an appropriate inflammatory response. Here, we show human monocyte-derived DCs (MDDCs), is able signaling intermediates downstream of Toll-like receptor (TLR) 4, such as and interferon regulatory factors (IRFs), resulting inhibition (IFN)-β expression. We also demonstrate itself IKK-e, kinase involved IFN-β production, which phosphorylates inactivates response TLR4 agonists. Thus, identify new IKK-e-controlled check-point IRF activation regulation expression, providing insight into role immune control.
mysciencework.com参考文章(43)
P Nakhaei, S Paz, J Hiscott, I Julkunen, R Romieu-Mourez, Q Sun, D Goubau, R Lin, Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway. Cellular and Molecular Biology. ,vol. 52, pp. 17- 28 ,(2006)
Mickey C.-T Hu, Dung-Fang Lee, Weiya Xia, Leonard S Golfman, Fu Ou-Yang, Jer-Yen Yang, Yiyu Zou, Shilai Bao, Norihisa Hanada, Hitomi Saso, Ryuji Kobayashi, Mien-Chie Hung, IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a Cell. ,vol. 117, pp. 225- 237 ,(2004) , 10.1016/S0092-8674(04)00302-2
Grigory Ryzhakov, Katrina Blazek, Irina A. Udalova, Evolution of Vertebrate Immunity: Sequence and Functional Analysis of the SEFIR Domain Family Member Act1 Journal of Molecular Evolution. ,vol. 72, pp. 521- 530 ,(2011) , 10.1007/S00239-011-9450-7
Thomas Krausgruber, David Saliba, Grigory Ryzhakov, Alessandra Lanfrancotti, Katrina Blazek, Irina A. Udalova, IRF5 is required for late-phase TNF secretion by human dendritic cells Blood. ,vol. 115, pp. 4421- 4430 ,(2010) , 10.1182/BLOOD-2010-01-263020
W. H. Biggs, J. Meisenhelder, T. Hunter, W. K. Cavenee, K. C. Arden, Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 7421- 7426 ,(1999) , 10.1073/PNAS.96.13.7421
Scott J. P. Thomson, Fui G. Goh, Helen Banks, Thomas Krausgruber, Sergei V. Kotenko, Brian M. J. Foxwell, Irina A. Udalova, The role of transposable elements in the regulation of IFN-λ1 gene expression Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 11564- 11569 ,(2009) , 10.1073/PNAS.0904477106
Wen Zhou, Qian Cao, Yan Peng, Qing–Jun Zhang, Diego H. Castrillon, Ronald A. DePinho, Zhi–Ping Liu, FoxO4 Inhibits NF-κB and Protects Mice Against Colonic Injury and Inflammation Gastroenterology. ,vol. 137, pp. 1403- 1414 ,(2009) , 10.1053/J.GASTRO.2009.06.049
D R Calnan, A Brunet, The FoxO code Oncogene. ,vol. 27, pp. 2276- 2288 ,(2008) , 10.1038/ONC.2008.21
Dimitris Thanos, Tom Maniatis, Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome Cell. ,vol. 83, pp. 1091- 1100 ,(1995) , 10.1016/0092-8674(95)90136-1
Tsuneyasu Kaisho, Takashi Tanaka, Turning NF-κB and IRFs on and off in DC Trends in Immunology. ,vol. 29, pp. 329- 336 ,(2008) , 10.1016/J.IT.2008.03.005