Clinical Trials and Sample Size Considerations: Another Perspective
作者： Marvin Zelen , Sandra J. Lee
关键词: Clinical trial 、 Bayesian statistics 、 Statistical power 、 Frequentist inference 、 Sample size determination 、 Outcome (probability) 、 Statistics 、 Empirical probability 、 Posterior probability 、 Computer science
摘要: We propose a Bayesian formulation of the sample size problem for planning clinical trials. The frequentist paradigm for calculating sizes trials is to prespecify type I and II error probabilities. These probabilities are conditional on true hypotheses. Instead we prespecifying posterior which the outcome trial. Our method easy implement has intuitive interpretations. illustrate an application our of cancer Eastern Cooperative Oncology Group (ECOG).
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J. O. Berger, B. Boukai, Y. Wang, Dennis V. Lindley, Thomas A. Louis, David Hinkley, J. O. Berger, B. Boukai, Y. Wang, Unified frequentist and Bayesian testing of a precise hypothesis Statistical Science. ,vol. 12, pp. 133- 160 ,(1997) , 10.1214/SS/1030037904
T. Pham-Gia, On Bayesian analysis, Bayesian decision theory and the sample size problem Journal of the Royal Statistical Society: Series D (The Statistician). ,vol. 46, pp. 139- 144 ,(1997) , 10.1111/1467-9884.00069
James O Berger, Benzion Boukai, Yinping Wang, Simultaneous Bayesian-frequentist sequential testing of nested hypotheses Biometrika. ,vol. 86, pp. 79- 92 ,(1999) , 10.1093/BIOMET/86.1.79
Dennis V. Lindley, The choice of sample size Journal of the Royal Statistical Society: Series D (The Statistician). ,vol. 46, pp. 129- 138 ,(1997) , 10.1111/1467-9884.00068
R Peto, M C Pike, P Armitage, N E Breslow, D R Cox, S V Howard, N Mantel, K McPherson, J Peto, P G Smith, Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. British Journal of Cancer. ,vol. 35, pp. 1- 39 ,(1977) , 10.1038/BJC.1977.1
Lawrence Joseph, Patrick Belisle, Bayesian sample size determination for normal means and differences between normal means The Statistician. ,vol. 46, pp. 209- 226 ,(1997) , 10.1111/1467-9884.00077
K.K.Gordon Lan, Lawrence Friedman, Monitoring boundaries for adverse effects in long-term clinical trials Controlled Clinical Trials. ,vol. 7, pp. 1- 7 ,(1986) , 10.1016/0197-2456(86)90002-4
Lawrence Joseph, David B. Wolfson, Roxane Du Berger, Sample Size Calculations for Binomial Proportions Via Highest Posterior Density Intervals The Statistician. ,vol. 44, pp. 143- 154 ,(1995) , 10.2307/2348439