Effective connectivity of the subthalamic nucleus - globus pallidus network during Parkinsonian oscillations

摘要: InParkinsonism,subthalamicnucleus(STN)neuronsandtwotypesofexternalglobus pallidus (GP) neuron inappropriately synchronise their firing in time with slow ( 1H z) or beta (13-30 Hz) oscillations cortex. We recorded the activities of STN, Type-I GP (GP-TI) and Type-A (GP-TA) neurons anaesthetised Parkinsonian rats during such to constrain a series computational models that systematically explored effective connections physiological parameters underlying neuronal rhythmic phase preferences vivo. The best candidate model, identified genetic algorithm optimising accuracy/complexity measures,faithfullyreproducedexperimentaldata andpredictedthat connectionsof GP-TI GP-TA are quantitatively different. Estimated inhibitory from striatum were much stronger than neurons, whereas excitatory thalamus STN neurons. Reciprocal between matched weight, but those not; only sent substantial back STN. Different connection weights within two types also evident. Adding differences, predicted have disparate intrinsic properties, reflected distinct autonomous