A multi-scale, mechanistic model of a wet granulation process using a novel bi-directional PBM–DEM coupling algorithm
作者： Dana Barrasso , Thomas Eppinger , Frances E. Pereira , Ravindra Aglave , Kristian Debus
DOI: 10.1016/J.CES.2014.11.011
关键词: Biological system 、 Population 、 Saturation (chemistry) 、 Material properties 、 Critical quality attributes 、 Quality by Design 、 Porosity 、 Engineering 、 Process engineering 、 Design space 、 Granulation
摘要: … In this study, a bi-directional coupling algorithm for PBM and DEM is presented and demonstrated for a twin-screw wet granulation process, developing a hybrid model to predict the …
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