The changing nature of the Brucella-Containing Vacuole

摘要: Bacteria of the Brucella genus are causative agent brucellosis, a zoonotic disease worldwide distribution that affects both animals and humans inflicts economical public health burden in endemic areas (Pappas et al., 2005). While brucellosis causes abortion sterility animals, human is characterized by recurrent fever debilitating musculoskeletal, cardiac neurological complications at chronic stage infection. primarily infects professional phagocytes such as macrophages or dendritic cells (Archambaud 2010) onset These act survival/replication niche vectors for systemic dissemination to other organs. subsequently infect myeloid lineage, including spleen liver, persist within granulomatous lesions, proliferate placental trophoblasts pregnant (Atluri 2011). pathological aspects emphasize importance bacterium’s intracellular cycle disease’s development progression, rationalize need understand underlying mechanisms its cycle. As bacteria have undergone long evolution with mammalian hosts, spp. selected sophisticated ensures their survival, immune evasion, proliferation persistence host, portraying an exquisite model pathogen subversion host cell organelles functions. Extensive studies revealed this controls conversion compartment, Brucella-containing vacuole (BCV), from endosomal (eBCV) replicative (rBCV) derived endoplasmic reticulum (ER) (Pizarro-Cerda, Moreno, 1998; Pizarro-Cerda, Meresse, Comerci 2001; Delrue Celli 2003; Salcedo 2008; Starr Salcedo, Chevrier, 2013), then subsequent biogenesis autophagy-related compartment (aBCV) (Starr 2012) (Fig. 1). Here I will review our current knowledge how modulates these sequential changes vacuole, emphasis on associated functions. Figure 1 Model trafficking