Immunology of Interferons: I. Immune Response to Protective and Nonprotective Interferons

摘要: Rabbits immunized with protective interferons prepared in allogeneic RK 13 and SIRC cells failed to develop neutralizing antibodies against either, although parallel groups of animals responded well repeated injections xenogeneic interferon L cells, which is non-protective for the rabbit host. All were guinea pigs elicited that species. Significant levels appeared also rabbits following immunization two derived from (human) cells. Immunologic analysis human four different types revealed minor antigenic variations may be detectable by means antibody neutralization assays.