The Diagnostic Accuracy of Urine Lipoarabinomannan Test for Tuberculosis Screening in a South African Correctional Facility
作者： Yasmeen Hanifa , Lilanganee Telisinghe , Katherine L. Fielding , Justin L. Malden , Gavin J. Churchyard
DOI: 10.1371/JOURNAL.PONE.0127956
关键词: Immunology 、 Gold standard (test) 、 Internal medicine 、 Urine 、 Medicine 、 Lipoarabinomannan 、 Mass screening 、 Population 、 Sputum 、 Tuberculosis 、 Chest radiograph
摘要: We evaluated the diagnostic accuracy of urine lipoarabinomannan (LAM) antigen detection assay (Clearview TB-ELISA) to screen for tuberculosis in a South African correctional facility. Between September 2009 and October 2010, male offenders were screened (symptoms, chest radiograph, two spot sputum specimens microscopy culture), tested LAM. Sensitivity, specificity predictive values LAM calculated using definite probable combined as our gold standard. 33/871 (3.8%) participants (26% HIV-positive) had tuberculosis. Amongst HIV-positive vs. HIV-negative sensitivity was 7.1% 0% 98.5% 99.8% respectively. Urine ELISA has inadequate TB screening this population.
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