A high throughput photosensitive polymer cantilever integrated with microelectrode array for drug-induced cardiac toxicity screening

摘要: This paper presents a high throughput photosensitive polymer cantilever device for real time monitor of drug-induced cardiac toxicity screening. The comprises micro-grooves and 3×3 microelectrode array on top its surface. optimized facilitate alignment cardiomyocytes thus greatly increase the contraction force generated by cardiomyocytes. Furthermore, is utilized to record extracellular impedance method employed measure both mechanical electrical performances was put forward first time. fabricated integrated with effective embody simultaneously. We demonstrate that proposed has ability identify relationship between cell impedance. assay results indicate combining effect provides depth understanding drug