Human therapeutic cloning, pitfalls and lack luster because of rapid developments in induced pluripotent stem cell technology
作者： Song Hua , Henry Chung , Kuldip Sidhu
DOI: 10.5372/1905-7415.0801.256
关键词: Viral vector 、 Immunology 、 Reprogramming 、 Somatic cell 、 Cell biology 、 Induced pluripotent stem cell 、 Cloning 、 Biology 、 Regenerative medicine 、 Embryonic stem cell 、 Somatic cell nuclear transfer
摘要: Background: Therapeutic cloning is the combination of somatic cell nuclear transfer (SCNT) and embryonic stem (ES) techniques to create specific ES cells that match those a patient. Because derived by (SCNT cells) are genetically identical donor, it will not generate rejection host's immune system thus therapeutically may be more acceptable. Induced pluripotent (iPS) type artificially from an adult inducing forced expression set ofspecific genes. In past few years, rapid progress in reprogramming iPS technology has been made, seems shadow any made SCNT programs. Objective: This review compares application perspective with regenerative medicine. Methods: We conducted literature search using MEDLINE (PubMed), Wiley InterScience, Springer, EBSCO, Annual Reviews databases keywords "iPS", "ES", "SCNT" "induced cells", "embryonic "therapeutic cloning", "regenerative medicine", "somatic transfer". Only articles published English were included this review. Results: These two methods both have advantages disadvantages. Nevertheless, patient-specific lines, eliminates complications avoiding use viral vectors during generation. Success vitro matured eggs aged women even differentiation oocytes germstem further enhance Conclusion: Human appropriate mean generating patient lines for clinical therapy near future. Keywords: iPS, review, SCNT, therapeutic
digitaljournals.org参考文章(43)
Young Chung, Colin E. Bishop, Nathan R. Treff, Stephen J. Walker, Vladislav M. Sandler, Sandy Becker, Irina Klimanskaya, Wan-Song Wun, Randall Dunn, Rebecca M. Hall, Jing Su, Shi-Jiang Lu, Marc Maserati, Young-Ho Choi, Richard Scott, Anthony Atala, Ralph Dittman, Robert Lanza, Reprogramming of human somatic cells using human and animal oocytes. Cloning and Stem Cells. ,vol. 11, pp. 213- 223 ,(2009) , 10.1089/CLO.2009.0004
Stojkovic Miodrag, Stojkovic Petra, Leary Christine, Jane Hall Vanessa, Armstrong Lyle, Herbert Mary, Nesbitt Maria, Lako Majlinda, Murdoch Alison, None, Derivation of a human blastocyst after heterologous nuclear transfer to donated oocytes. Reproductive Biomedicine Online. ,vol. 11, pp. 226- 231 ,(2005) , 10.1016/S1472-6483(10)60962-5
Kevin Eggan, Kristin Baldwin, Michael Tackett, Joseph Osborne, Joseph Gogos, Andrew Chess, Richard Axel, Rudolf Jaenisch, Mice cloned from olfactory sensory neurons Nature. ,vol. 428, pp. 44- 49 ,(2004) , 10.1038/NATURE02375
Kitchener D. Wilson, Shivkumar Venkatasubrahmanyam, Fangjun Jia, Ning Sun, Atul J. Butte, Joseph C. Wu, MicroRNA Profiling of Human-Induced Pluripotent Stem Cells Stem Cells and Development. ,vol. 18, pp. 749- 758 ,(2009) , 10.1089/SCD.2008.0247
John Gurdon, Primate therapeutic cloning in practice. Nature Biotechnology. ,vol. 26, pp. 64- 65 ,(2008) , 10.1038/NBT0108-64
Dieter Egli, Alice E. Chen, Genevieve Saphier, Douglas Powers, Michael Alper, Karin Katz, Brian Berger, Robin Goland, Rudolph L. Leibel, Douglas A. Melton, Kevin Eggan, Impracticality of egg donor recruitment in the absence of compensation. Cell Stem Cell. ,vol. 9, pp. 293- 294 ,(2011) , 10.1016/J.STEM.2011.08.002
Alex Bortvin, Kevin Eggan, Helen Skaletsky, Hidenori Akutsu, Deborah L Berry, Ryuzo Yanagimachi, David C Page, Rudolf Jaenisch, Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development. ,vol. 130, pp. 1673- 1680 ,(2003) , 10.1242/DEV.00366
Thomas P. Zwaka, What comes after iPS Nature Reports Stem Cells. pp. 1- 1 ,(2008) , 10.1038/STEMCELLS.2008.54
R. K. Ng, J. B. Gurdon, Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 1957- 1962 ,(2005) , 10.1073/PNAS.0409813102
Kuldip S Sidhu, John P Ryan, Bernie E Tuch, None, Derivation of a new human embryonic stem cell line, endeavour-1, and its clonal propagation. Stem Cells and Development. ,vol. 17, pp. 41- 51 ,(2008) , 10.1089/SCD.2007.0055