Method for identifying compounds that control the translational activity of ribosomal proteins in differential mRNA expression
作者： Hannelore Breitenbach-Koller , Olaf Haubenreisser , Johann Bauer , Helmut Hintner
DOI:
关键词: Eukaryotic cell 、 Ribosomal protein 、 Epidermolysis bullosa 、 Gene 、 Translation (biology) 、 Molecular biology 、 Disease 、 Biochemistry 、 Mutant 、 Mrna expression 、 Biology
摘要: The present invention relates to systems and methods for screening compounds and/or mutant ribosomal proteins in a eukaryotic cell that increase or decrease the translation of target gene thereby ameliorate revert defective undesired gene. Disclosed are as identified with invention, pharmaceutical cosmetic compositions thereof, their uses preparation medicament, treatment disease condition related gene, example genetic diseases such Epidermolysis bullosa, well diagnostic measures practical clinical evaluation conditions. Also, kits provided which comprise addition suitable means performing
lens.org 参考文章(44)
Nahum Sonenberg, Michael B. Mathews, John W. B. Hershey, Translational control in biology and medicine Cold Spring Harbor Laboratory Press. ,(2007)
Elke Sadler, Martin Laimer, Anja Diem, Alfred Klausegger, Gabriele Pohla-Gubo, Wolfgang Muss, Johannes Hachleitner, Rudolf Stadlhuber, Johann W Bauer, Helmut Hintner, Zahnveränderung bei junktionaler Epidermolysis bullosa – Bericht über eine Patientin mit einer Mutation im LAMB3‐Gen Journal Der Deutschen Dermatologischen Gesellschaft. ,vol. 3, pp. 359- 363 ,(2005) , 10.1111/J.1610-0387.2005.05703.X
Andrea Vasella, Sven N. Hobbie, Erik C. Boettger, Screening assay for ribosomal antibiotics ,(2007)
Allan S. Jacobson, Feng He, HETEROLOGOUS POLYPEPTIDE PRODUCTION IN THE ABSENCE OF NONSENSE-MEDIATED mRNA DECAY FUNCTION ,(1995)
Alfonso R. Gennaro, Joseph P. Remington, Remington's pharmaceutical sciences Published in <b>1975</b> in Easton Pa) by Mack. ,(1985)
M. Laimer, C.M. Lanschützer, E. Nischler, A. Klausegger, A. Diem, G. Pohla-Gubo, J.W. Bauer, H. Hintner, Epidermolysis bullosa hereditaria Monatsschrift Kinderheilkunde. ,vol. 156, pp. 110- 121 ,(2008) , 10.1007/S00112-007-1663-X
Neil Gregory Almstead, Robert F. Rando, Mathew C. Pellegrini, Ellen M. Welch, METHODS FOR IDENTIFYING SMALL MOLECULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY ,(2003)
William Henry Irwin McLean, Frances Jane Dorothy Smith, Prevention/treatment of ichthyosis vulgaris, atopy and other disorders ,(2007)
Peter Laun, Gino Heeren, Mark Rinnerthaler, Raphaela Rid, Sonja Kössler, Lore Koller, Michael Breitenbach, Senescence and apoptosis in yeast mother cell-specific aging and in higher cells : A short review Biochimica et Biophysica Acta. ,vol. 1783, pp. 1328- 1334 ,(2008) , 10.1016/J.BBAMCR.2008.02.008