Controlled and Localized Release of Retinoids to Improve Neointimal Hyperplasia
作者： Melina Kibbe , Guillermo A. Ameer , Antonio Webb
DOI:
关键词: Chemistry 、 Cancer research 、 Retinoic acid 、 Surgery 、 Controlled release 、 Neointimal hyperplasia 、 Thrombosis 、 Downregulation and upregulation 、 Cell growth 、 Antithrombotic 、 Nitric oxide
摘要: Controlled release vascular implants, such as grafts, stents, wraps, and gels comprising a biocompatible polymer all trans retinoic acid (ATRA), or its derivatives, can be used to treat, prevent, inhibit thrombosis and/or neointimal hyperplasia which may otherwise induced by prosthetic implantation. In particular, the implants herein smooth muscle cell proliferation, hyperplasia, upregulate antithrombotic genes nitric oxide production in vasculature. Further, are capable of delivering controlled predictable localized concentrations ATRA.
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