Synthesis of a fullerene derivative for the inhibition of HIV enzymes

摘要: A diamido diacid diphenyl fulleroid derivative was designed specifically to inhibit an HIV enzyme. The detailed synthesis and mass spectrometric analysis of the water-soluble, biologically active methanofullerene are described. compound prepared in three steps from C[sub 60] via a suitably diphenyldiazomethane. High-resolution possible only under mild matrix-assisted laser desorption/ionization Fourier transform spectrometry conditions. Direct infrared or ultraviolet desorption resulted exclusively observation ions, either positive negative mode. 13 refs., 3 figs.