Use of icos-based cars to enhance antitumor activity and car persistence
作者： Carl H. June , John Scholler , Sonia Guedan Carrio , Yangbing Zhao
DOI:
关键词: Cell biology 、 Genetically modified organism 、 Transmembrane domain 、 Antitumor activity 、 Antigen binding 、 Intracellular 、 Domain (software engineering) 、 Chemistry 、 Immunology 、 Cell
摘要: The present invention provides compositions and methods for treating cancer in a human. includes administering genetically modified Thl7 cell to express CAR having an antigen binding domain, transmembrane ICOS intracellular signaling domain.
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