Expression of nitric oxide synthase in human central nervous system tumors.

摘要: Abstract The nitric oxide synthases (NOS) are a family of related enzymes which regulate the production NO, free radical gas implicated in wide variety biological processes. Vasodilation and increased tumor blood flow, vascular permeability, modulation host tumoricidal activity, injury to cells adjacent normal tissues pathophysiological features malignant tumors that may be mediated by NO. We examined human brain for three NOS isoforms NADPH diaphorase, histochemical marker activity brain. detected expression endothelial forms [NOS I II, respectively (C. Nathan Q. Xie. Cell, 78: 915–919, 1994)] astrocytic tumors, highest levels was found higher grade tumors. Each these two cells. macrophage isoform (NOS III) less frequently expressed at lower level, predominantly diaphorase staining paralleled this pattern expression. Western blot analysis confirmed observations. Our data indicate central nervous system neoplasms express unexpectedly high suggest NO associated with processes important