Safety and efficacy of simultaneous corneal collagen cross-linking with topography-guided PRK in managing low-grade keratoconus: 1-year follow-up.

摘要: PURPOSE To evaluate 1-year visual and topographic outcomes safety efficacy of corneal collagen cross-linking (CXL) combined with topography-guided photorefractive keratectomy (TG-PRK) to achieve near emmetropia in eyes low-grade keratoconus. METHODS Twenty-two from 15 patients (11 women, 4 men) were included a prospective, nonrandomized, noncontrolled clinical study. Mean patient age was 26.6±6.07 years (range: 19 40 years). Inclusion criteria keratoconus evidence progression, transparent cornea, corrected distance acuity (CDVA) 0.8 (decimal) or better, thickness >440 μm, maximum keratometry readings (K-max) <51.00 diopters (D). All underwent simultaneous TG-PRK CXL. Study parameters uncorrected acuity, CDVA, manifest refractive error, (corneal) astigmatism, satisfaction, the treatment. Follow-up 1 year. RESULTS After year, statistically significant improvement noted all study (P<.01). The indices 1.6 0.4, respectively. Patient satisfaction questionnaire showed that 91% satisfied, 9% not completely satisfied but believed they improved, none dissatisfied. Corneal topography demonstrated 55%, 36%, minor cases. No cases progressed as evidenced by readings. CONCLUSIONS Simultaneous CXL is an effective safe treatment remarkable who meet recommended inclusion criteria.