The role of leukocytes in ischemic damage, reperfusion injury and repair of the myocardium

摘要: The response to occlusion of a coronary artery in dogs was first described by Chirac 1698 [2], thereby preceding the clinical recognition myocardial infarction. Although it is acknowledged that treatment any pathologic process can be carried out intelligently and scientifically only when based on thorough understanding how lesion develops resolves, speed with which these processes occur [3], almost 300 years later events involved defining ultimate extent injury remain poorly understood. Yet histologic changes acute infarction develop relatively slowly [4], have been documented extensively (see references [5–7] for review). Moreover, as ischemic heart disease major cause premature morbidity mortality western world, there multitude studies pathogenesis myocellular necrosis influenced variety different interventions, leading Braunwald [8] conclude, “Just because tissue lies within distribution recently occluded artery, does not mean necessarily condemned cell death.”