Health-related quality of life in postmenopausal women with low BMD with or without prevalent vertebral fractures.

摘要: Fractures and subsequent morbidity determine the impact of established postmenopausal osteoporosis. Health-related quality life (HRQOL) has become an important outcome criterion in assessment follow-up osteoporotic patients. As part baseline measurements Multiple Outcomes Raloxifene Evaluation (MORE) study, HRQOL was assessed 751 (bone mineral density [BMD] T score > or = -2.5) women from Europe with without vertebral fractures (VFX). This done using questionnaire European Foundation for Osteoporosis (QUALEFFO), Nottingham Health Profile (NHP) EQ-5D (former EuroQol). QUALEFFO contains questions five domains: pain, physical function, social general health perception, mental function. Each domain total scores are expressed on a 100-point scale, 0 corresponding to best HRQOL. In comparison patients VFX, those VFX were older (66.2 +/- 5.9 years vs. 68.8 6.3 years; p < 0.001), had higher prevalence nonvertebral (25% 36%; 0.002), (worse HRQOL; score, 26 14 36 17; 0.001). increased progressively increasing number especially lumbar (p Patients single already significant increase 0.05). Similar, though weaker, associations seen NHP scores. study confirms decreased prevalent VFX. patients, change relation is suitable clinical studies