COMPARATIVE ANALGESIC ACTIVITY OF LEVOMEPROMAZINE AND MORPHINE IN PATIENTS WITH CHRONIC PAIN.

摘要: Apart from its ability to potentiate the action of narcotics, levomepromazine, a phenothiazine derivative, was shown possess own analgesic activity comparable that morphine at 3:2 dose relationship. In double-blind crossover study 18 patients suffering chronic pain (cancer and arthritis), levomepromazine (15 mg.) compared with (10 placebo. Three hours after intramuscular administration, proved be significantly superior placebo (p < .05) indistinguishable morphine. Evaluations relief by estimations changes in intensity were found correlate well evaluations based on recognition exceeding 50%. The potent effect obtained price excessive sedation. This, however, considered an acceptable side patient pain. These results provide encouragement quest for non-addicting substitute