Dendritic Cell-Based Vaccine for the Treatment of Malignant Glioma: A Systematic Review

作者: Xuan Wang , Hong-Yang Zhao , Fang-Cheng Zhang , Yun Sun , Zhi-Yong Xiong

DOI: 10.3109/07357907.2014.958234

关键词: GlioblastomaDendritic cellImmunotherapyComparative trialPoor prognosisImmunologyOncologyInternal medicineClinical trialGliomaMedicineSurvival rate

摘要: Objective: Glioblastoma multiforme (GBM) has a poor prognosis. The purpose of this systematic review and meta-analysis was to analyze the outcomes clinical trials which compared immunotherapy with conventional therapy for treatment malignant gliomas. Methods: PubMed, Cochrane Google Scholar databases were searched relevant studies. 2-year survival rate used evaluate effectiveness immunotherapy. Results: Of 171 studies identified, six comparative included in review. Immunotherapy associated significantly longer OS therapy. Conclusion: may improve patients GBM.

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