Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma

作者: Surasak Phuphanich , Christopher J. Wheeler , Jeremy D. Rudnick , Mia Mazer , HongQian Wang

DOI: 10.1007/S00262-012-1319-0

关键词:

摘要: Background This study evaluated the safety and immune responses to an autologous dendritic cell vaccine pulsed with class I peptides from tumor-associated antigens (TAA) …

参考文章(30)
Kaoru Tamura, Masaru Aoyagi, Hiroaki Wakimoto, Noboru Ando, Tadashi Nariai, Masaaki Yamamoto, Kikuo Ohno, Accumulation of CD133-positive glioma cells after high-dose irradiation by Gamma Knife surgery plus external beam radiation. Journal of Neurosurgery. ,vol. 113, pp. 310- 318 ,(2010) , 10.3171/2010.2.JNS091607
Qijin Xu, Gentao Liu, Xiangpeng Yuan, Minlin Xu, Hongqiang Wang, Jianfei Ji, Bindu Konda, Keith L. Black, John S. Yu, Antigen-specific T-cell response from dendritic cell vaccination using cancer stem-like cell-associated antigens. Stem Cells. ,vol. 27, pp. 1734- 1740 ,(2009) , 10.1002/STEM.102
Dwain K. Irvin, Emmanuel Jouanneau, Gretchen Duvall, Xiao-xue Zhang, Yuying Zhai, Danielle Sarayba, Akop Seksenyan, Akanksha Panwar, Keith L. Black, Christopher J. Wheeler, T Cells Enhance Stem-Like Properties and Conditional Malignancy in Gliomas PLoS ONE. ,vol. 5, pp. e10974- ,(2010) , 10.1371/JOURNAL.PONE.0010974
Gentao Liu, John S. Yu, Gang Zeng, Dong Yin, Dong Xie, Keith L. Black, Han Ying, AIM-2: a novel tumor antigen is expressed and presented by human glioma cells. Journal of Immunotherapy. ,vol. 27, pp. 220- 226 ,(2004) , 10.1097/00002371-200405000-00006
Gentao Liu, Hung T. Khong, Christopher J. Wheeler, John S. Yu, Keith L. Black, Han Ying, Molecular and functional analysis of tyrosinase-related protein (TRP)-2 as a cytotoxic T lymphocyte target in patients with malignant glioma. Journal of Immunotherapy. ,vol. 26, pp. 301- 312 ,(2003) , 10.1097/00002371-200307000-00002
Stéphan Saikali, Tony Avril, Brigitte Collet, Abderrahmane Hamlat, Jean-Yves Bansard, Bernard Drenou, Yvon Guegan, Véronique Quillien, Expression of nine tumour antigens in a series of human glioblastoma multiforme: interest of EGFRvIII, IL-13Rα2, gp100 and TRP-2 for immunotherapy Journal of Neuro-oncology. ,vol. 81, pp. 139- 148 ,(2006) , 10.1007/S11060-006-9220-3
Gerold Schuler, Beatrice Schuler-Thurner, Ralph M Steinman, The use of dendritic cells in cancer immunotherapy Current Opinion in Immunology. ,vol. 15, pp. 138- 147 ,(2003) , 10.1016/S0952-7915(03)00015-3
Roberto Pallini, Lucia Ricci-Vitiani, Nicola Montano, Cristiana Mollinari, Mauro Biffoni, Tonia Cenci, Francesco Pierconti, Maurizio Martini, Ruggero De Maria, Luigi Maria Larocca, Expression of the stem cell marker CD133 in recurrent glioblastoma and its value for prognosis Cancer. ,vol. 117, pp. 162- 174 ,(2011) , 10.1002/CNCR.25581
Xiangpeng Yuan, James Curtin, Yizhi Xiong, Gentao Liu, Sebastian Waschsmann-Hogiu, Daniel L Farkas, Keith L Black, John S Yu, Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene. ,vol. 23, pp. 9392- 9400 ,(2004) , 10.1038/SJ.ONC.1208311
S. H. van der Burg, M. Kalos, C. Gouttefangeas, S. Janetzki, C. Ottensmeier, M. J. P. Welters, P. Romero, C. M. Britten, A. Hoos, Harmonization of Immune Biomarker Assays for Clinical Studies Science Translational Medicine. ,vol. 3, pp. 108ps44- 108ps44 ,(2011) , 10.1126/SCITRANSLMED.3002785