Dissected peripancreatic tissue margin is a critical prognostic factor and is associated with a K‑ras gene mutation in pancreatic ductal adenocarcinoma

摘要: We previously reported that the dissected pancreatic tissue margin (DPM) and preoperative serum level of carbohydrate antigen 19-9 (preCA19-9) were independent prognostic factors in ductal adenocarcinoma (PDAC). In current study, relevance these factors, including their molecular associations, validated. A total 161 patients with PDAC underwent a pancreatectomy between 1986 2013, multivariate Cox proportional hazards model propensity score-based validated importance DPM. The compared mutation profiles K-ras TP53 genes. Univariate analysis disease-specific survival (DSS) demonstrated DPM (P<0.0001), preCA19-9 (P<0.0001) Union for International Cancer Control (UICC) stage all significantly associated poor outcome PDAC. confirmed (P=0.0002) remained as UICC (P=0.0015). combination to predict prognosis could accurately identify long-term survivors (70% 5-year DSS), logistic regression identified was most effective predictor mortality. also (P=0.0008) through background adjustment patient bias. gene (P=0.0002), DPM-positive recurrence distant metastasis 67% cases. Therefore, is critical indicator preCA19-9, may be useful Furthermore, best our knowledge, study first discover can represent based putatively on its association mutation.