Streptococcus pneumoniae Capsular Polysaccharide.
作者： James C. Paton , Claudia Trappetti
DOI: 10.1128/MICROBIOLSPEC.GPP3-0019-2018
关键词: Carriage 、 Quorum sensing 、 Disease 、 Molecular genetics 、 Streptococcus pneumoniae 、 Bacterial genetics 、 Serotype 、 Biology 、 Virulence 、 Microbiology
摘要: The polysaccharide capsule of Streptococcus pneumoniae is the dominant surface structure organism and plays a critical role in virulence, principally by interfering with host opsonophagocytic clearance mechanisms. target current pneumococcal vaccines, but there are 98 currently recognised serotypes protection strictly serotype-specific. Widespread use these vaccines driving changes serotype prevalence both carriage disease. This chapter summarises knowledge on its regulation pathogenesis, mechanisms synthesis, genetic basis for differences, provides insights into how so many structurally distinct capsular have evolved. Such will inform ongoing refinement vaccination strategies.
asmscience.org
cabdirect.org 参考文章(135)
U B Skov Sørensen, J Blom, A Birch-Andersen, J Henrichsen, Ultrastructural localization of capsules, cell wall polysaccharide, cell wall proteins, and F antigen in pneumococci. Infection and Immunity. ,vol. 56, pp. 1890- 1896 ,(1988) , 10.1128/IAI.56.8.1890-1896.1988
Catherine Hyams, Emilie Camberlein, Jonathan M. Cohen, Katie Bax, Jeremy S. Brown, The Streptococcus pneumoniae capsule inhibits complement activity and neutrophil phagocytosis by multiple mechanisms. Infection and Immunity. ,vol. 78, pp. 704- 715 ,(2010) , 10.1128/IAI.00881-09
Janet Yother, Capsules of Streptococcus pneumoniae and Other Bacteria: Paradigms for Polysaccharide Biosynthesis and Regulation Annual Review of Microbiology. ,vol. 65, pp. 563- 581 ,(2011) , 10.1146/ANNUREV.MICRO.62.081307.162944
Abiodun D. Ogunniyi, Layla K. Mahdi, Claudia Trappetti, Nadine Verhoeven, Daphne Mermans, Mark B. Van der Hoek, Charles D. Plumptre, James C. Paton, Identification of Genes That Contribute to the Pathogenesis of Invasive Pneumococcal Disease by In Vivo Transcriptomic Analysis Infection and Immunity. ,vol. 80, pp. 3268- 3278 ,(2012) , 10.1128/IAI.00295-12
Melanie Abeyta, Gail G. Hardy, Janet Yother, Genetic Alteration of Capsule Type but Not PspA Type Affects Accessibility of Surface-Bound Complement and Surface Antigens of Streptococcus pneumoniae Infection and Immunity. ,vol. 71, pp. 218- 225 ,(2003) , 10.1128/IAI.71.1.218-225.2003
Mara G. Shainheit, Matthew Mulé, Andrew Camilli, The Core Promoter of the Capsule Operon of Streptococcus pneumoniae Is Necessary for Colonization and Invasive Disease Infection and Immunity. ,vol. 82, pp. 694- 705 ,(2014) , 10.1128/IAI.01289-13
Laura R. Marks, Ryan M. Reddinger, Anders P. Hakansson, High Levels of Genetic Recombination during Nasopharyngeal Carriage and Biofilm Formation in Streptococcus pneumoniae Mbio. ,vol. 3, ,(2012) , 10.1128/MBIO.00200-12
R. Marsh, H. Smith-Vaughan, K. M. Hare, M. Binks, F. Kong, J. Warning, G. L. Gilbert, P. Morris, A. J. Leach, The Nonserotypeable Pneumococcus: Phenotypic Dynamics in the Era of Anticapsular Vaccines Journal of Clinical Microbiology. ,vol. 48, pp. 831- 835 ,(2010) , 10.1128/JCM.01701-09
Catherine Hyams, Krzysztof Trzcinski, Emilie Camberlein, Daniel M. Weinberger, Suneeta Chimalapati, Mahdad Noursadeghi, Marc Lipsitch, Jeremy S. Brown, Streptococcus pneumoniae Capsular Serotype Invasiveness Correlates with the Degree of Factor H Binding and Opsonization with C3b/iC3b Infection and Immunity. ,vol. 81, pp. 354- 363 ,(2013) , 10.1128/IAI.00862-12
Catherine Hyams, Jose Yuste, Katie Bax, Emilie Camberlein, Jeffrey N. Weiser, Jeremy S. Brown, Streptococcus pneumoniae resistance to complement-mediated immunity is dependent on the capsular serotype. Infection and Immunity. ,vol. 78, pp. 716- 725 ,(2010) , 10.1128/IAI.01056-09