Other Dietary Confounders: FODMAPS et al.

摘要: Background: While it is well documented and widely appreciated that ingestion of wheat (and less so rye barley) associated with gastrointestinal symptoms such as bloating or abdominal pain, the component to which an effect attributed established. Key Messages: Wheat a complex proteins (80% gluten, 20% metabolic proteins), carbohydrates (starch, non-starch polysaccharides, fructans), lipids other components. The majority attention has focused on gluten culprit in triggering symptoms, but re-challenge studies have nearly all used flour-related products (such bread) stimulus. When carbohydrate-deplete was challenge agent, gluten-specific feelings depression not gut were observed those who fulfilled strict criteria ‘non-coeliac sensitivity', thereby underlining complexity cereals undertaking research this area. Candidate components than include poorly absorbed oligosaccharides (mainly non-gluten amylase-trypsin inhibitors germ agglutinin, exorphins released during digestion gluten. Specific biological and/or clinical effects gluten-free diets need be carefully dissected before attribution can claimed. Conclusions: Currently, coeliac disease only common condition been unequivocally linked Inaccurate will suboptimal therapeutic advice at least partly underlies current epidemic gripping Western world.